Govt. Exams
Entrance Exams
The relative refractory period occurs during repolarization when membrane potential is more negative than resting potential (hyperpolarized). A suprathreshold stimulus can overcome this increased threshold to generate an action potential.
The ascending limb actively transports Na+/K+/Cl- without water permeability, creating osmotic gradients that concentrate urine in the collecting duct.
Nephrotic syndrome involves damage to the glomerular filtration barrier (podocytes), increasing permeability to plasma proteins like albumin.
Depolarization occurs when voltage-gated Na+ channels open, allowing rapid Na+ influx that reverses membrane potential towards positive values.
Dystrophin protein deficiency causes Duchenne muscular dystrophy, an X-linked recessive disorder affecting muscle structure and function.